Let’s Work Together

Fill out the form below and we’ll get back to you shortly.

Join Our Team   

Who are we?

Founded in 2021 in San Diego, Molecular Axiom aspires to become a global leader in nucleic acid drug discovery, clinical development, and commercialization. Our core expertise encompasses a wide range of RNA technologies including ASO, RNAi, mRNA, as well as enabling drug delivery technologies such as LNP. We aim to create clearly differentiated products for big unmet medical needs by drugging biological targets with substantial genetic validation. We value individual ingenuity and the spirit of collaboration to achieve company goals and advance breakthrough therapy for the benefits of patients.

Our leaders’ broad background and experience creates an exciting scientific discovery environment which helps our researchers focus on pioneering solutions to answer difficult questions in pharmaceutical research.

We foster a changing and continuously growing inclusive culture of excellence where everyone in the team encouraged to learn and grow. As an Equal Opportunity Employer, our capabilities and business practices support diverse ideas and people in order to cultivate and motivate a culturally diverse workforce.

Career Opportunities

In Vitro Scientist

 

Who are you?

As an in Vitro Scientist, you will conduct animal studies on potential drug candidates for pharmacokinetic/pharmacodynamic (PK/PD) and efficacy evaluation using disease models, as well as preclinical drug tolerance and DMPK investigations to support IND enabling studies. You will also work closely with nucleic acid delivery scientists to evaluate the biodistribution of delivery systems and payload to demonstrate efficacy and safety. In addition, you will work with our drug development team in managing IND enabling studies conducted at CROs. Your ultimate goal is to leverage your experience and knowledge to help Molecular Axiom advance nucleic acid-based therapies into preclinical and clinical development.

We’re looking for candidates who have a can-do attitude and embrace and thrive in our vibrant and collaborative start-up culture. You are not only expected to be an independent scientific contributor, but also a ready collaborator with your teammates. You will speak up in team discussions and participate in the decision-making process. You must be willing to lead and be led, help, and be helped, and enjoy the close professional relationships at work striving to achieve the company’s objectives and vision.

Responsibilities including, but not limited to:

    • Execute PK/PD, target engagement, efficacy, or mechanism of action studies to support pre-clinical and discovery programs.
    • Administer nucleic acid-based test articles to mice, measure endpoints (i.e., tumor volume, body weight) and collect blood/tissue for analysis.
    • Prepare test articles for animal studies and perform end point assays with samples from in vivo studies.
    • Analyze in vivo studies and present scientific and technical data in project meetings
    • Manage and serve as liaison for the vivarium facility, and manage study protocols for IACUC approval.
    • Work with internal stakeholders and external collaborators to support IND studies.
    • Authoring study and technical reports to support regulatory agency requests.

Requirements & Technical Skills:

    • Degree in Biological Sciences or equivalent, industry and nucleic acid medicine experience preferred. The title and compensation are commensurate with experience.
    • Expert hands-on experience in various dosing routes (SC, IV, IP, IT, ICV), blood collection (sub mandibular, terminal cardiac, retro orbital), necropsy, and tumor/organ collection is required.
    • Experience in at least one of the oncology, immunology and CNS animal models is required.
      For oncology, hands-on experience working with CDX and/or PDX models is required, including tumor establishment and measurement. Ability to establish new tumor cell line xenograft in mice, and familiar with orthotopic tumor model is highly desired.
    • For immunology, experience in autoimmune disease models, and treatment to modify immune response is required.
    • For CNS, experience in neurodegenerative disease models and endpoint assays to measure disease progression is required.
    • Experience in the management of animal study CROs and production of study protocol per IACUC requirement and animal study regulatory compliance is required.
    • Strong collaboration, problem solving, and communication skills.
    • Strong skills in documentation and timeline management.

 

Molecular Axiom is an equal opportunity employer. All aspects of employment including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.

 

In Vivo Scientist

 

Who are you?

As an in Vivo Scientist, you will conduct animal studies on potential drug candidates for pharmacokinetic/pharmacodynamic (PK/PD) and efficacy evaluation using disease models, as well as preclinical drug tolerance and DMPK investigations to support IND enabling studies. You will also work closely with nucleic acid delivery scientists to evaluate the biodistribution of delivery systems and payload to demonstrate efficacy and safety. In addition, you will work with our drug development team in managing IND enabling studies conducted at CROs. Your ultimate goal is to leverage your experience and knowledge to help Molecular Axiom advance nucleic acid-based therapies into preclinical and clinical development.

We’re looking for candidates who have a can-do attitude and embrace and thrive in our vibrant and collaborative start-up culture. You are not only expected to be an independent scientific contributor, but also a ready collaborator with your teammates. You will speak up in team discussions and participate in the decision-making process. You must be willing to lead and be led, help, and be helped, and enjoy the close professional relationships at work striving to achieve the company’s objectives and vision.

Responsibilities including, but not limited to:

    • Execute PK/PD, target engagement, efficacy, or mechanism of action studies to support pre-clinical and discovery programs.
    • Administer nucleic acid-based test articles to mice, measure endpoints (i.e., tumor volume, body weight) and collect blood/tissue for analysis.
    • Prepare test articles for animal studies and perform end point assays with samples from in vivo studies.
      Analyze in vivo studies and present scientific and technical data in project meetings
    • Manage and serve as liaison for the vivarium facility, and manage study protocols for IACUC approval.
    • Work with internal stakeholders and external collaborators to support IND studies.
    • Authoring study and technical reports to support regulatory agency requests.

Requirements & Technical Skills:

    • Degree in Biological Sciences or equivalent, industry and nucleic acid medicine experience preferred. The title and compensation are commensurate with experience.
    • Expert hands-on experience in various dosing routes (SC, IV, IP, IT, ICV), blood collection (sub mandibular, terminal cardiac, retro orbital), necropsy, and tumor/organ collection is required.
    • Experience in at least one of the oncology, immunology and CNS animal models is required.
    • For oncology, hands-on experience working with CDX and/or PDX models is required, including tumor establishment and measurement. Ability to establish new tumor cell line xenograft in mice, and familiar with orthotopic tumor model is highly desired.
    • For immunology, experience in autoimmune disease models, and treatment to modify immune response is required.
    • For CNS, experience in neurodegenerative disease models and endpoint assays to measure disease progression is required.
    • Experience in the management of animal study CROs and production of study protocol per IACUC requirement and animal study regulatory compliance is required.
    • Strong collaboration, problem solving, and communication skills.
      Strong skills in documentation and timeline management.

 

Molecular Axiom is an equal opportunity employer. All aspects of employment including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.

Nucleic Acid Delivery Scientist

 

Who are you?

As a Nucleic Acid Delivery Scientist, you will produce and optimize formulations with nucleic acid payload to enable in vitro and in vivo evaluation of the delivery vehicles. You will also characterize the delivery vehicles with various analytical methods, including size, surface charge and encapsulation efficiency measurements. You will dissect the manufacturing process, and are expected to be able to perfect the steps to meet the acceptance criteria consistently, help the scale up process, and perform technology transfer to CMOs. You will work closely with the internal team to enable in vitro and in vivo evaluation and identify innovative technologies externally to create novel vehicles. Your ultimate goal is to leverage your experience and knowledge to help Molecular Axiom advance nucleic acid-based therapies into clinical development.

We’re looking for candidates who have a can-do attitude and embrace and thrive in our vibrant and collaborative start-up culture. You are not only expected to be an independent scientific contributor, but also a ready collaborator with your teammates. You will speak up in team discussions and participate in the decision-making process. You must be willing to lead and be led, help, and be helped, and enjoy the close professional relationships at work striving to achieve the company’s objectives and vision.

Responsibilities including, but not limited to:

    • Produce formulations for various nucleic acid payloads. Prepare test articles for animal studies and characterize the formulations pre- and post- dosing to ensure study quality.
    • Work with in vivo scientists to design the Pharmacology and DMPK studies, and forecast and manage material requirements and timelines.
    • Analyze the data and present the formulation work in meetings and identify potential modifications to improve the function of the vehicles.
    • Identify potential and promising nucleic acid technologies, verify the validity experimentally, and recommend to management a path forward.
    • Author technology reports and SOPs and manage technology establishment and transfer to facilitate project progression.

Requirements & Technical Skills:

    • Degree in Biological Sciences or equivalent, industry and nucleic acid medicine experience preferred. The title and compensation are commensurate with experience.
    • Hands-on experience with producing at least one type of nucleic acid delivery vehicles (liposomes, lipid nanoparticle, polymers, and exosome) and familiar with targeting technology including peptides, lipids, ligands, aptamers, etc.
    • Experience with methods to adjust the concentrations of vehicles to proper levels (dialysis, centrifugation and TFF) and storage conditions is required.
    • Experience with various formulation characterization methodologies is required, including size, charge, uniformity, endotoxin contains, encapsulation efficiency. Knowledge of purification of the vehicles and standard formulation stability requirement is desired.
    • Strong collaboration, problem solving, attention to details and communication skills.
      Strong skills in documentation and timeline management.

 

Molecular Axiom is an equal opportunity employer. All aspects of employment including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.